Chalcone derived benzoheterodiazepines for medicinal applications:<scp>A Two‐pot</scp>and<scp>one‐pot</scp>synthetic approach

The production of effective drugs has continuously been a challenging process for researchers due to the occurrence resistive diseases. Drugs derived from natural product-based compounds as an active scaffold have gained interest in drug development wide range biological properties. Benzoheterodiazepines, product derivative bicyclic chalcones widely reported with various therapeutic potentials. This review discusses current synthetic methods preparation benzoheterodiazepine derivatives (i.e., homocyclic benzoheterodiazepine, heterocyclic bis-benzoheterodiazepine, and fused benzoheterodiazepine) via two-pot one-pot routes. Several reaction protocols following both routes developed efficient higher yields that offer access different functionalization benzoheterodiazepines are comprehensively described. is important chemistry pharmacological industries processes.